Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Scale-Up Processes01:14

Scale-Up Processes

89
The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
89
Introduction to Statistical Process Control01:15

Introduction to Statistical Process Control

828
Statistical Process Control (SPC) is a method used to monitor and control quality within processes, particularly in manufacturing and service delivery, by employing statistical methods. SPC aims to distinguish between natural (common cause) variation and variation due to specific changes or events (special cause), allowing for timely improvements and sustained quality. The control chart, a pivotal tool in SPC, visually displays data over time alongside a central line of upper and lower control...
828
Reducing Line Loss01:18

Reducing Line Loss

451
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss...
451
Pipe Flowrate Measurement: Problem Solving01:28

Pipe Flowrate Measurement: Problem Solving

1.0K
A spray tank system is engineered to uniformly distribute a pest-control liquid across plants by using a pressurized mechanism. The tank, pressurized to 150 kPa, holds the pesticide at a height of 0.80 meters. Liquid flows from the tank through a 1.9 meter pipe with a diameter of 0.015 meters, angled at 0.698 radians, ultimately reaching a 0.007 meter nozzle that sprays the pesticide. Accurate calculation of the system's flow rate is crucial to ensure uniform application, and this is achieved...
1.0K
Upstream Processing01:27

Upstream Processing

87
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
87
Production Efficiency01:01

Production Efficiency

19.1K
Net production efficiency (NPE) is the efficiency at which organisms assimilate energy into biomass for the next trophic level. Due to low metabolic rates and less energy spent on thermoregulatory processes, the NPE of ectotherms (cold-blooded animals) is 10 times higher than endotherms (warm-blooded animals).
19.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-clinical studies of Schistosoma mansoni vaccines: A scoping review.

PLoS neglected tropical diseases·2025
Same author

Sabin inactivated polio vaccine upstream process development using fixed-bed bioreactor technology.

Vaccine·2025
Same author

Non-coding RNAs to treat vascular smooth muscle cell dysfunction.

British journal of pharmacology·2024
Same author

High throughput AS LNA qPCR method for the detection of a specific mutation in poliovirus vaccine strains.

Vaccine·2024
Same author

Development of an animal component free production process for Sabin inactivated polio vaccine.

Vaccine: X·2022
Same author

Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development.

Journal of virology·2021
Same journal

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine·2026
Same journal

Safety and immunogenicity of a reduced, homologous booster dose of the BNT162b2 mRNA COVID-19 vaccine: a single blind, randomized, non-inferiority follow-up trial.

Vaccine·2026
Same journal

Vaccination policies for healthcare personnel in Europe, 2026.

Vaccine·2026
Same journal

A historical overview of the anti-vaccine movement and its public health implications.

Vaccine·2026
Same journal

Vaccine strategies and development before and during the 1968 H3N2 influenza pandemic.

Vaccine·2026
Same journal

Influence of correlated vaccination behaviors on estimates of COVID-19 vaccine effectiveness in older adults - VISION network, October 2023 - March 2024.

Vaccine·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.8K

sIPV process development for costs reduction.

Yvonne E Thomassen1, Wilfried A M Bakker1

  • 1Institute for Translational Vaccinology, PO Box 450, 3720 AL Bilthoven, The Netherlands.

Vaccine
|April 11, 2015
PubMed
Summary
This summary is machine-generated.

Polio eradication is nearing, necessitating a shift to inactivated polio vaccines (IPV). This study presents a new, cost-effective IPV production process using Sabin strains to meet future demand.

Keywords:
Cost of goodsInactivated polio vaccineProcess optimizationSabin poliovirus

More Related Videos

Automated Deployment of an Internet Protocol Telephony Service on Unmanned Aerial Vehicles Using Network Functions Virtualization
07:49

Automated Deployment of an Internet Protocol Telephony Service on Unmanned Aerial Vehicles Using Network Functions Virtualization

Published on: November 26, 2019

8.6K
VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders
08:57

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders

Published on: August 3, 2016

11.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.8K
Automated Deployment of an Internet Protocol Telephony Service on Unmanned Aerial Vehicles Using Network Functions Virtualization
07:49

Automated Deployment of an Internet Protocol Telephony Service on Unmanned Aerial Vehicles Using Network Functions Virtualization

Published on: November 26, 2019

8.6K
VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders
08:57

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders

Published on: August 3, 2016

11.6K

Area of Science:

  • Vaccinology
  • Virology
  • Bioprocess Engineering

Background:

  • Global polio eradication is imminent, leading to the cessation of oral polio vaccines.
  • A transition to inactivated polio vaccines (IPV) is planned post-eradication.
  • Current IPV production methods, developed in the 1960s, require optimization for increased demand and biosafety.

Purpose of the Study:

  • To present a novel strategy for setting up an inactivated polio vaccine (IPV) production process.
  • To explore cost reduction measures for IPV manufacturing.
  • To review the impact of process optimization on the cost of single inactivated polio vaccine (sIPV).

Main Methods:

  • Development of a new IPV production process utilizing attenuated Sabin polio virus strains.
  • Investigation of yield optimization strategies for cost reduction.
  • Analysis of alternative, more biosafe polio virus strains for manufacturing.

Main Results:

  • A new IPV production strategy using Sabin strains has been established.
  • Process optimization studies are underway to reduce manufacturing costs.
  • The potential for cost reduction in sIPV production through process improvements has been assessed.

Conclusions:

  • The presented strategy offers a viable approach for future IPV production.
  • Process optimization is crucial for meeting increased IPV demand and reducing costs.
  • The transition to Sabin strain-based IPV production enhances manufacturing biosafety and cost-effectiveness.