[Unresolved and debatable questions on the problem of appendicitis].

Area of Science:

• Pathology
• Gastroenterology
• Surgical Pathology

Background:

• Appendicitis is a complex condition with debated classifications.
• Distinguishing chronic appendicitis from senile involution is clinically relevant.
• The existence and diagnostic criteria for primary chronic appendicitis remain unclear.

Purpose of the Study:

• To histomorphologically examine appendix specimens to clarify appendicitis definitions.
• To investigate criteria for differentiating chronic appendicitis from senile involution.
• To explore the existence of primary chronic appendicitis.

Main Methods:

• Histomorphologic examination of 9907 appendix biopsy specimens from appendicitis cases.
• Analysis of 228 appendix specimens from cases of senile involution.
• Examination of appendix specimens from 125 pediatric patients.

Main Results:

• The study provides a basis for debating poorly defined aspects of appendicitis.
• It assumes the existence of chronic appendicitis and primary chronic appendicitis.
• Sufficient morphologic criteria are believed to exist for distinguishing chronic appendicitis from senile involution.

Conclusions:

• Chronic appendicitis, including primary forms, likely exists.
• Histomorphologic criteria can differentiate chronic appendicitis from senile involution.
• Further clarification of appendicitis classification is warranted.