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Clinical Analysis of 134 Children with Nervous System Damage Caused by Enterovirus 71 Infection

Yue Hu1, Li Jiang, Hai-lun Peng

  • 1From the *Department of Neurology, Children's Hospital Affiliated to Chongqing University of Medical Sciences, Chongqing, China; †Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; ‡Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002, Chongqing, China; and §Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.

The Pediatric Infectious Disease Journal
|April 11, 2015
PubMed

Insights

Enterovirus 71 (EV71) infection in children commonly causes fever and neurological issues like meningitis or paralysis. However, most pediatric patients recover fully with prompt diagnosis and supportive care.

Area of Science:

  • Virology
  • Neurology
  • Pediatrics

Background:

  • Enterovirus 71 (EV71) is a significant pathogen causing neurological damage in children.
  • Understanding the clinical spectrum of EV71-related nervous system damage is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the clinical characteristics of nervous system damage in pediatric patients due to enterovirus 71 (EV71) infection.

Main Methods:

  • Retrospective analysis of clinical data from 134 laboratory-confirmed pediatric EV71 infections.
  • Data collected from Children's Hospital of Chongqing Medical University between January and December 2013.

Main Results:

  • EV71 infection peaked in children aged 1-4 years, males, and during spring/summer months.
  • Common symptoms included fever; neurological complications ranged from aseptic meningitis to acute flaccid paralysis (AFP).
  • Magnetic resonance imaging revealed specific brain and spinal cord lesions in affected patients; most patients showed full recovery.

Conclusions:

  • Early diagnosis and supportive treatment are key for favorable outcomes in pediatric EV71 infections.
  • EV71 infection in children, while potentially severe, generally has a good prognosis with appropriate medical management.
Abstract

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