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Close encounters of the lysosome-peroxisome kind
Yui Jin1, Bethany S Strunk1, Lois S Weisman1
1Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Cell
|April 11, 2015
Abstract:
Lysosomes provide a major source for cellular cholesterol; however, most of this cholesterol is trafficked to the plasma membrane via unknown mechanisms. Chu et al. identify an unexpected role for peroxisomes in the transport of cholesterol from the lysosome to the plasma membrane via a lysosome-peroxisome membrane contact site.
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