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Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Pericarditis I: Introduction01:22

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Pericarditis III: Medical Management01:17

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The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Probable hydrochlorothiazide-induced myopericarditis: first case reported.

Toufik Mahfood Haddad1, Muhammad Sarfraz Nawaz1, Ahmed S Abuzaid1

  • 1Department of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USA.

Case Reports in Medicine
|April 11, 2015
PubMed
Summary
This summary is machine-generated.

Hydrochlorothiazide (HCTZ) may cause myopericarditis, a rare condition. This case suggests HCTZ allergy as a potential cause of myopericarditis in patients with hypertension, prompting medication review.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Immunology

Background:

  • Myopericarditis is inflammation of the heart muscle and pericardium.
  • Hydrochlorothiazide (HCTZ) is a common diuretic used for hypertension.
  • HCTZ-induced myopericarditis is exceptionally rare, with limited literature.

Purpose of the Study:

  • To report a case of myopericarditis potentially linked to hydrochlorothiazide (HCTZ).
  • To highlight the possibility of HCTZ as an etiological agent for myopericarditis.
  • To contribute to the limited existing literature on drug-induced pericardial disease.

Main Methods:

  • Case report of a patient with hypertension and sulfa allergy.
  • Clinical presentation: chest pain, elevated inflammatory markers (ESR), and troponin.
  • Diagnostic workup: Transthoracic echocardiogram (TTE) to assess cardiac function and pericardial effusion.

Main Results:

  • Patient presented with symptoms consistent with myopericarditis.
  • Laboratory tests showed elevated erythrocyte sedimentation rate (ESR) and troponin.
  • Transthoracic echocardiogram revealed moderate pericardial effusion without tamponade.

Conclusions:

  • Hydrochlorothiazide (HCTZ) is hypothesized as the cause of myopericarditis in this patient.
  • This case underscores the importance of considering drug reactions, even rare ones, in diagnosing myopericarditis.
  • Discontinuation of HCTZ and anti-inflammatory treatment are recommended management strategies.