Prophylactic antibiotic administration for post cardiothoracic surgery sternal wounds: a retrospective study
Georgia Pitsiou1, Ioannis Kioumis1, Konstantinos Zarogoulidis1
11 Pulmonary Department, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 2 Department of Medical Oncology, Aristotle University School of Medicine, Thessaloniki, Greece ; 3 2nd Pulmonary Clinic of "Sotiria" Hospital, Athens, Greece ; 4 Pulmonary Laboratory of Alexandra Hospital University of Athens, Athens, Greece ; 5 Nuclear Medicine Department, University General Hospital of Alexandroupolis, Democritus University of Thrace, Greece ; 6 Thoracic Surgery Department, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Vancomycin is an effective prophylactic antibiotic for cardiothoracic surgery, reducing sternal wound infections. This study found vancomycin superior to begalin and beneficial for male patients, with shorter pre-surgery hospitalization improving outcomes.
Area of Science:
- Infectious Diseases
- Surgical Outcomes
- Pharmacology
Background:
- Cardiothoracic surgery sternal infections present significant treatment challenges.
- Current prophylactic antibiotic guidelines for these infections are lacking.
Purpose of the Study:
- To evaluate the efficacy of vancomycin as a prophylactic antibiotic in cardiothoracic surgery.
- To compare vancomycin with begalin for preventing post-sternal wound infections.
Main Methods:
- Retrospective analysis of 535 patients undergoing cardiothoracic surgery.
- Collection of biological parameters and surgical technical aspects.
- Comparison of infection rates between vancomycin and begalin groups.
Main Results:
- Vancomycin administration was associated with fewer post-surgery sternal infections compared to begalin.
- Male patients receiving vancomycin showed improved treatment outcomes.
- Hospitalization exceeding 7 days pre-surgery increased infection risk by 62.6%.
Conclusions:
- Vancomycin demonstrates efficacy as a prophylactic agent for cardiothoracic surgeries.
- Vancomycin effectively reduces the incidence of sternal wound infections.
- Optimizing pre-surgical hospitalization duration is crucial for infection prevention.
