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Generalized overgrowth syndromes with prenatal onset

Naomi Yachelevich1

  • 1Clinical Genetics Services, New York University Hospitals Center, New York, NY.

Current Problems in Pediatric and Adolescent Health Care
|April 12, 2015
PubMed

Insights

Generalized overgrowth syndromes in children cause excessive growth and may increase cancer risk. Early identification is key for management, counseling, and tumor surveillance.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Oncology

Background:

  • Generalized overgrowth syndromes are characterized by large birth size or excessive postnatal growth in children.
  • These conditions are frequently linked to an elevated risk of developing neoplasms (cancers).
  • Recognizing overgrowth syndromes is crucial for effective pediatric care, including reproductive guidance and cancer monitoring.

Purpose of the Study:

  • To review the clinical features of common generalized overgrowth syndromes in pediatric patients.
  • To outline surveillance recommendations for these syndromes.
  • To provide insight into the molecular basis of disrupted growth regulation in these disorders.

Main Methods:

  • Literature review of generalized overgrowth syndromes.
  • Analysis of clinical presentations and diagnostic criteria.
  • Summary of current surveillance protocols and recent molecular findings.

Main Results:

  • Detailed description of clinical manifestations, including growth parameters, malformations, and neurodevelopmental aspects.
  • Identification of key features for differential diagnosis in pediatric patients.
  • Overview of recommended tumor surveillance strategies for specific overgrowth syndromes.

Conclusions:

  • Prompt recognition of overgrowth syndromes is vital for comprehensive pediatric medical management.
  • Understanding the molecular mechanisms aids in developing targeted therapies and improved prognoses.
  • This review equips pediatricians with essential knowledge for managing children with overgrowth conditions.

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