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Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing
Bohua Ding1, Yongmei Tian, Yangang Pan
1School of Physics, Northeast Normal University, Changchun, Jilin 130024, P.R. China. sunyc149@nenu.edu.cn.
Nanoscale
|April 14, 2015
Abstract:
We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.

