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Updated: Apr 15, 2026
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The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens
Published on: April 24, 2018
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Increased epicardial adipose tissue volume is associated with PR interval prolongation
Wei-Chin Hung1, Wei-Hua Tang, Chao-Ping Wang
1. email@email.com.
Summary
Increased epicardial adipose tissue (EAT) volume is associated with PR-interval prolongation. This finding highlights a potential link between EAT and cardiac conduction abnormalities.
Area of Science:
- Cardiology
- Radiology
- Biomedical Engineering
Background:
- Epicardial fat (EAT) is inflammatory visceral adipose tissue.
- Obesity and inflammation are linked to cardiovascular disease and arrhythmias.
- The relationship between EAT and PR-interval prolongation is not well understood.
Purpose of the Study:
- To investigate the association between epicardial adipose tissue (EAT) volume and PR-interval prolongation.
- To utilize computed tomography (CT) and Twelve-lead ECGs for assessment.
Main Methods:
- 287 patients referred for CT for coronary artery disease exclusion.
- EAT volumes determined by 64-slice CT.
- Twelve-lead ECGs evaluated by two independent readers.
Main Results:
- Patients with PR-interval prolongation had higher median EAT volume.
- Significant correlations found between EAT volume and PR interval (p = 0.003) and QRS duration (p = 0.018).
- EAT volume >144.4 cm³ was associated with PR-interval prolongation.
Conclusions:
- EAT volume is strongly associated with PR-interval prolongation.
- Further research is needed to determine EAT's role in the pathogenesis of PR-interval prolongation.
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