Design, synthesis and initial characterisation of a radiolabelled [(18)F]pyrimidoindolone probe for detecting
A Udemba1, G Smith, Q-D Nguyen
1Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK. e.aboagye@imperial.ac.uk.
Organic & Biomolecular Chemistry
|April 14, 2015
Abstract:
Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.
