Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

2.8K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A microfluidic hollow-fiber infection model (µHFIM): monitoring bacterial response to dynamic drug treatment with single-cell resolution.

Microsystems & nanoengineering·2026
Same author

Opposing range-dependent interactions create complex spatial patterns of antibiotic tolerance in multispecies biofilms.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Nested Nanowell Arrays for High-Throughput Quantitative Analysis of Cytokines from Single Macrophages.

ACS nano medicine·2026
Same author

Towards nanoparticle analysis using N<sub>2</sub> MICAP-MS: Employed gases, carbon enhancement, and alcohol tolerance.

Talanta·2026
Same author

Corrigendum to "Directed evolution of an integral membrane monooxygenase unlocks its full potential" [Bioresour. Technol. 447 (2026) 134249].

Bioresource technology·2026
Same author

Directed evolution of an integral membrane monooxygenase unlocks its full potential.

Bioresource technology·2026

Related Experiment Video

Updated: Apr 15, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.9K

A microfluidic chip for ICPMS sample introduction.

Pascal E Verboket1, Olga Borovinskaya1, Nicole Meyer1

  • 1Department of Chemistry and Applied Biosciences, ETH Zurich.

Journal of Visualized Experiments : Jove
|April 14, 2015
PubMed
Summary

A new microfluidic chip offers a low-cost sample introduction for inductively coupled plasma mass spectrometry (ICPMS). This system generates uniform droplets for precise elemental analysis, even in single cells.

More Related Videos

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

8.6K
A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.5K

Related Experiment Videos

Last Updated: Apr 15, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.9K
Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

8.6K
A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.5K

Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Mass Spectrometry

Background:

  • Inductively coupled plasma mass spectrometry (ICPMS) requires efficient sample introduction systems.
  • Existing systems can be costly and complex.
  • Microfluidic devices offer potential for miniaturized and cost-effective analytical tools.

Purpose of the Study:

  • To develop and evaluate a disposable, low-cost microfluidic chip for sample introduction into ICPMS.
  • To demonstrate the chip's ability to produce monodisperse aqueous droplets.
  • To assess the system's performance for quantitative elemental analysis.

Main Methods:

  • Fabrication of a disposable microfluidic chip.
  • Generation of aqueous sample droplets in perfluorohexane (PFH).
  • Utilizing a custom desolvation system for PFH removal and droplet transport to ICPMS.

Main Results:

  • The microfluidic chip successfully produced monodisperse aqueous droplets (40-60 µm) at variable frequencies (90-7,000 Hz).
  • Stable ICPMS signals with narrow intensity distributions confirmed droplet monodispersity.
  • Quantitative determination of iron in single bovine red blood cells was achieved.

Conclusions:

  • The developed microfluidic chip serves as an effective and low-cost sample introduction system for ICPMS.
  • The system enables precise analysis of small sample volumes, including single cells.
  • Future integration of microfluidic modules can expand the system's analytical capabilities.