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An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects
Published on: January 9, 2020
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Raman spectroscopy in pharmaceutical product design.
Amrit Paudel1, Dhara Raijada2, Jukka Rantanen2
1Research Center Pharmaceutical Engineering GmbH (RCPE), Graz, Austria.
Advanced Drug Delivery Reviews
|April 15, 2015
Summary
Raman spectroscopy and microscopy offer non-invasive biomedical analysis for drug discovery and delivery systems. These advanced techniques are crucial for pharmaceutical development, quality control, and future innovations.
Area of Science:
- Biomedical Sciences
- Analytical Chemistry
- Pharmaceutical Sciences
Background:
- Raman scattering, discovered nearly a century ago, has evolved into vital analytical tools for biomedical applications.
- Raman spectroscopy and microscopy are non-invasive techniques with broad utility in diverse biomedical fields.
Purpose of the Study:
- To review conventional and emerging Raman instrumentation and hyphenated techniques relevant to the pharmaceutical industry.
- To introduce applications of Raman spectroscopy in pharmaceutical development, process analysis, and drug delivery system characterization.
- To discuss future advancements and applications of Raman spectroscopic techniques.
Main Methods:
- Review of literature on Raman spectroscopy and microscopy.
- Description of various Raman instrumentations and hyphenated techniques.
- Compilation of application cases in pharmaceutical development and drug delivery.
Main Results:
- Raman spectroscopy and microscopy are versatile tools for molecular-based drug discovery, drug delivery system design, and quality control.
- Applications span early and late-phase pharmaceutical development, process analysis, and micro-structural analysis.
- Various conventional and emerging Raman instrumentations, including hyphenated tools, are presented.
Conclusions:
- Raman spectroscopic techniques are indispensable for modern pharmaceutical research and development.
- The non-invasive nature and molecular specificity of Raman methods offer significant advantages.
- Future advancements promise expanded applications in drug discovery, delivery, and manufacturing.
Keywords:
Dissolution testingDrug deliveryDrug developmentFormulationPreformulationProcess analytical technologiesQuality controlSolid-stateMore Related Videos
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