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Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Cannabis and cardiotoxicity.

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  • 1Consultant in Cardiac Pathology/Toxicology, P.O. Box 5139, 94705, Berkeley, CA, kalimantantimor@yahoo.com.

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Summary
This summary is machine-generated.

Despite its popularity, cannabis use rarely causes cardiovascular events like stroke. Research suggests the cardiovascular risks associated with cannabinoids may be comparable to smoking cigarettes, not as severe as some studies indicate.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Cannabinoid Science

Background:

  • Cannabis is the most frequently used illicit drug globally, with millions consuming marijuana annually.
  • Despite widespread use, cannabis-associated cardiovascular events such as myocardial infarction and stroke are exceptionally rare.
  • Cannabinoids, active marijuana compounds, have complex cardiovascular effects, interacting with both central and peripheral systems.

Purpose of the Study:

  • To investigate the cardiovascular safety of cannabis and its active compounds.
  • To reconcile conflicting findings from animal and in vitro studies on cannabinoid cardiotoxicity.
  • To assess the real-world cardiovascular risk associated with cannabis consumption.

Main Methods:

  • Review of existing literature on cannabis use and cardiovascular events.
  • Analysis of conflicting results from preclinical (animal and in vitro) studies.
  • Consideration of clinical data, including the use of dronabinol (synthetic THC) in cancer patients.

Main Results:

  • Cannabis-related stroke and myocardial infarction are infrequently reported, despite high global usage rates.
  • Preclinical studies present contradictory findings regarding the cardiotoxic potential of cannabinoids.
  • No cardiotoxicity has been observed in cancer patients treated with dronabinol.

Conclusions:

  • The cardiovascular risks associated with cannabis use are likely lower than suggested by some animal studies.
  • The cardiotoxicity risk of cannabis may be comparable to that of smoking traditional cigarettes.
  • Further research is warranted to fully elucidate the cardiovascular impact of cannabinoids in humans.