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Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza R Mazid1, R Vijayaraghavan, Douglas R MacFarlane

  • 1Department of Chemical Engineering, Monash University, Clayton 3800, VIC, Australia. wenlong.cheng@monash.edu.

Chemical Communications (Cambridge, England)
|April 15, 2015
PubMed

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

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