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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Types of RNA

Types of RNA

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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The Landscape of long noncoding RNA classification.

Georges St Laurent¹, Claes Wahlestedt², Philipp Kapranov³

¹St. Laurent Institute, 317 New Boston St., Suite 201, Woburn, MA 01801 USA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting Street, Providence, RI 02912, USA.

Trends in Genetics : TIG

|April 15, 2015

Summary

This summary is machine-generated.

The study reviews long noncoding RNA (lncRNA) classifications, highlighting the need for a clear framework. It proposes guidelines for lncRNA classification and functional annotation using systems biology data.

Keywords:

annotation of long non-coding RNAs classification of long non-coding RNAs function of long non-coding RNAs lincRNA lncRNA long non-coding RNA systems biology transcriptome vlincRNA

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Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Transcriptome sequencing advances reveal numerous long noncoding RNAs (lncRNAs).
Current lncRNA classification systems are complex and lack standardization.
Ambiguous terminology hinders understanding of lncRNA function and annotation.

Purpose of the Study:

To review existing long noncoding RNA (lncRNA) classification systems, nomenclature, and terminology.
To address the challenges posed by the lack of a clear conceptual framework for lncRNA annotation and interpretation.
To propose conceptual guidelines for lncRNA classification and functional annotation.

Main Methods:

Comprehensive review of existing literature on lncRNA classification and terminology.
Analysis of current challenges in noncoding transcriptome data annotation and interpretation.
Development of proposed guidelines based on systems biology datasets.

Main Results:

Identified a proliferation of lncRNA classes and associated terminology.
Highlighted the ambiguity and lack of clarity in the field due to inconsistent nomenclature.
Recognized the need for a unified conceptual framework for lncRNA classification.

Conclusions:

A standardized and unambiguous classification framework is crucial for advancing lncRNA research.
Proposed guidelines aim to improve the annotation and interpretation of noncoding transcriptome data.
Integration of systems biology approaches is key to unraveling lncRNA functions.