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Measuring Biomarker Progress.

J A Wagner1, A J Atkinson2

  • 1Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.

Clinical Pharmacology and Therapeutics
|April 15, 2015
PubMed
Summary
This summary is machine-generated.

Biomarkers are objective medical measurements indicating biological processes or treatment responses. Since their 1999 definition, biomarker research has rapidly expanded, evidenced by over 200,000 PubMed citations.

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Area of Science:

  • Biomedical Science
  • Clinical Research
  • Translational Medicine

Background:

  • A consensus conference in 1999 defined biomarkers as objectively measured characteristics indicating biological processes or therapeutic responses.
  • This definition encompasses physiological measurements, blood tests, molecular analyses, genetic data, and imaging data.

Discussion:

  • The 1999 definition has significantly advanced biomarker research and applications.
  • Biomarker research has seen exponential growth, with a substantial increase in scientific publications.

Key Insights:

  • Biomarkers serve as crucial indicators in understanding health and disease.
  • The broad definition facilitates diverse applications across medical research.

Outlook:

  • Continued expansion of biomarker discovery and validation is expected.
  • Biomarkers will play an increasingly vital role in personalized medicine and drug development.