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Cervical Cancer, Version 2.2015.

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  • 1From Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Washington/Seattle Cancer Care Alliance; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; University of Michigan Comprehensive Cancer Center; Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; University of Colorado Cancer Center; Roswell Park Cancer Institute; Huntsman Cancer Institute at the University of Utah; City of Hope Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Fred & Pamela Buffett Cancer Center; Stanford Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Duke Cancer Institute; UC San Diego Moores Cancer Center; and National Comprehensive Cancer Network.

Journal of the National Comprehensive Cancer Network : JNCCN
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PubMed
Summary
This summary is machine-generated.

Updated NCCN Guidelines for Cervical Cancer include new systemic therapy options for advanced disease and guidance on surgical staging. Key changes reflect new survival data and bevacizumab approval for recurrent or metastatic cervical cancer.

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Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Clinical Practice Guidelines

Background:

  • The National Comprehensive Cancer Network (NCCN) Guidelines for Cervical Cancer offer crucial interdisciplinary treatment recommendations.
  • Previous guidelines required updates to reflect advancements in systemic therapy and surgical staging.

Purpose of the Study:

  • To summarize key updates to the NCCN Cervical Cancer Guidelines from 2014-2015.
  • To provide insights into panel decisions regarding systemic therapy for recurrent and metastatic cervical cancer.
  • To introduce new guidance on cervical cancer evaluation and surgical staging.

Main Methods:

  • Review of NCCN Cervical Cancer Panel discussions and guideline revisions.
  • Analysis of new survival data for systemic therapies.
  • Inclusion of FDA-approved treatments like bevacizumab for advanced cervical cancer.

Main Results:

  • Systemic therapy recommendations for recurrent and metastatic cervical cancer were amended based on new data and bevacizumab approval.
  • New guidance on the principles of evaluation and surgical staging for cervical cancer was added.
  • Active areas of investigation, including sentinel lymph node mapping and fertility-sparing options, were highlighted.

Conclusions:

  • The updated NCCN Guidelines for Cervical Cancer incorporate critical advancements in systemic therapy and surgical staging.
  • These revisions aim to optimize treatment strategies for patients with recurrent and metastatic cervical cancer.
  • Ongoing research in sentinel lymph node mapping and fertility-sparing treatments is emphasized.