[Pathways of intra-articular transport of cholesterol esters]

The authors have carried out an experimental study of an insufficiently explored problem of the diffusion capacity of the ethers of cholesterol through the skin and the possibility of their intra-articular transport with cholesterol ether of the oleic acid marked 1,2(3)H taken as an example. It has been established that the drug penetrates through the skin and appears in the joint cavity. The results expand our ideas of the biological role of lipids and present the arguments in favour of the hypothesis of their participation in the mechanism of reduction of intra-articular friction.