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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

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Serotonin and the bone assessment.

M Carsote¹, V Radoi², A Geleriu³

¹"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.

Journal of Medicine and Life

|April 15, 2015

Summary

Serum serotonin shows inconsistent correlations with bone turnover markers and bone mineral density in postmenopausal women. Further research is needed to clarify its role in skeletal health evaluation.

Keywords:

Alkaline Phosphatase CrossLaps Osteocalcin osteoporosis serotonin

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Area of Science:

Endocrinology
Bone Metabolism
Biochemistry

Background:

Emerging research suggests serotonin metabolism influences bone health.
Current clinical practice lacks recommendations for serum serotonin assessment in evaluating skeletal status.

Purpose of the Study:

To investigate the correlation between serum serotonin levels and bone turnover markers (serum alkaline phosphatase, serum osteocalcin, serum CrossLaps) and lumbar bone mineral density (BMD) in Caucasian postmenopausal women.

Main Methods:

A cross-sectional study involving 191 Caucasian postmenopausal women without carcinoid syndrome or bone anomalies.
Measurements included serum serotonin (high-pressure liquid chromatography), bone formation markers (serum alkaline phosphatase, serum osteocalcin), bone resorption marker (serum CrossLaps), and central DXA for BMD.
Participants were grouped according to WHO criteria for osteoporosis and osteopenia.

Main Results:

Serum serotonin showed a statistically significant correlation with osteocalcin in the newly diagnosed osteoporosis group (N=40).
A statistically significant correlation was found between serum serotonin and alkaline phosphatase in the osteopenia group (N=88).
No statistically significant correlation was observed between serum serotonin and CrossLaps or lumbar bone mineral density.

Conclusions:

The findings suggest inconsistent associations between serum serotonin and bone metabolism markers, questioning its utility as a sole marker for skeletal status.
Limitations include the lack of analysis for antidepressant use.
This pilot study highlights the need for further investigation into the role of serum serotonin in skeletal evaluation.