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Differential Gene Expression in Diabetic Nephropathy in Individuals With Type 1 Diabetes

M Luiza Caramori1, Youngki Kim1, Allison B Goldfine1

  • 1Departments of Medicine and Pediatrics (M.L.C., M.M.), and Pediatrics and Laboratory Medicine and Pathology (Y.K.), University of Minnesota, Minneapolis, Minnesota 55455; Joslin Diabetes Center (A.B.G., A.S.K.), Harvard Medical School, Boston, Massachusetts 02115; Department of Genetics (J.H.M.), Institute for Biomedical Informatics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, Dartmouth College, Hanover, New Hampshire 03755; Departments of Public Health Sciences (S.S.R.), and Bioinformatics and Genetics (J.C.M.), University of Virginia, Charlottesville, Virginia 22908; Department of Genetics (D.K.), Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455; and JDRF (H.N.), New York, New York 10004.

The Journal of Clinical Endocrinology and Metabolism
|April 15, 2015
PubMed
Summary

Skin fibroblasts from type 1 diabetes patients without diabetic nephropathy show enhanced gene expression in cell cycle and repair pathways, suggesting epigenetic modifications influence DN risk.

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