Related Experiment Video

Updated: Apr 15, 2026

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.5K

[The progress of TRP channels in structural studies]

Di-Jing Shi, Ke-Wei Wang

    Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
    |April 16, 2015
    PubMed

    More Related Videos

    Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy08:27

    Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

    Published on: January 7, 2019

    10.1K
    Purification of Endogenous Drosophila Transient Receptor Potential Channels08:39

    Purification of Endogenous Drosophila Transient Receptor Potential Channels

    Published on: December 28, 2021

    2.3K

    Related Concept Videos

    Thermosensation01:43

    Thermosensation

    Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
    35.6K
    Mechanically-gated Ion Channels01:12

    Mechanically-gated Ion Channels

    Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
    8.2K
    Mechanically-gated Ion Channels01:12

    Mechanically-gated Ion Channels

    5.8K
    Voltage-gated Ion Channels01:26

    Voltage-gated Ion Channels

    Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
    Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
    13.7K
    Cotranslational Protein Translocation01:20

    Cotranslational Protein Translocation

    Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
    Sec61 channel partners for cotranslational translocation
    During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
    11.2K
    Ligand-gated Ion Channels01:19

    Ligand-gated Ion Channels

    Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
    Three Subfamilies of Ligand-gated Ion Channels
    Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
    15.6K