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Ultrasound Cyclo Plasty in Eyes with Glaucoma
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[Options for prolonging the hypotensive effect of trabeculectomy]
S Yu Petrov1, А А Antonov1, А S Makarova1
1Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
Vestnik Oftalmologii
|April 16, 2015
Summary
Preoperative anti-inflammatory therapy, including steroid and non-steroid drugs, improved trabeculectomy success rates. Combination therapy showed the most significant hypotensive effect, enhancing long-term outcomes in glaucoma patients.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Pharmacology
Context:
- Trabeculectomy is a common surgical procedure for glaucoma.
- Postoperative hypotensive effect is crucial for successful glaucoma management.
- The use of anti-inflammatory drugs before surgery is being investigated to improve outcomes.
Purpose:
- To evaluate the efficacy of preoperative topical steroid and non-steroid anti-inflammatory drugs (SAIDs and NSAIDs) in prolonging the hypotensive effect of trabeculectomy.
- To compare the outcomes of different anti-inflammatory drug regimens versus a control group.
Summary:
- A randomized trial involving 80 primary open-angle glaucoma patients undergoing trabeculectomy compared preoperative treatment with nepafenac, dexamethasone, a combination, or no therapy.
- Preoperative anti-inflammatory therapy reduced the need for postoperative interventions like needling and hypotensive medications.
- The combination therapy group achieved the highest one-year complete success rate (80%), followed by steroid monotherapy (75%) and NSAID monotherapy (65%), compared to the control group (50%).
Impact:
- Preoperative anti-inflammatory therapy significantly enhances the one-year success rate of trabeculectomy.
- Combination therapy with nepafenac and dexamethasone offers the most substantial improvement in hypotensive effect.
- These findings suggest a valuable adjunctive strategy for optimizing glaucoma surgery outcomes.
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