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Cytomegalovirus-related childhood mortality in Australia 1999-2011

Hayley Smithers-Sheedy1,2,3, Camille Raynes-Greenow1,2, Nadia Badawi1,2,3

  • 1Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|April 16, 2015
PubMed

Insights

Cytomegalovirus (CMV) contributes to a small but significant number of childhood deaths in Australia, primarily affecting infants under 12 months. This highlights the impact of severe congenital CMV disease.

Area of Science:

  • Pediatric Infectious Diseases
  • Public Health Surveillance
  • Neonatal Mortality

Background:

  • Cytomegalovirus (CMV) is a significant cause of congenital infections with potential for neonatal mortality.
  • Post-natal CMV infection is less common, primarily affecting preterm or immunocompromised children.
  • Understanding CMV's role in childhood mortality in Australia is crucial for public health strategies.

Purpose of the Study:

  • To quantify the direct or secondary contribution of Cytomegalovirus (CMV) to childhood mortality in Australia.
  • To analyze trends and characteristics of CMV-associated deaths in children under 15 years.

Main Methods:

  • National mortality datasets from 1999-2011 were analyzed.
  • Cases under 15 years with CMV as an underlying or contributing cause of death were identified.
  • Mortality rates and years of potential life lost were calculated.

Main Results:

  • Eighty-three CMV-associated deaths in children under 15 years were identified.
  • The majority of deaths (68%) occurred in infants under 12 months, with 22 cases under 1 month.
  • The mortality rate remained stable, with an estimated 5925 years of potential life lost.

Conclusions:

  • CMV represents a small but important factor in Australian childhood mortality.
  • Infant deaths underscore the burden of severe congenital CMV disease.
  • Further research into congenital CMV prevention and management is warranted.
Abstract

Keywords:
Australiacytomegalovirusmortality

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