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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

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Association between divorce and risks for acute myocardial infarction.

Matthew E Dupre¹, Linda K George², Guangya Liu²

¹From the Duke Clinical Research Institute (M.E.D., E.D.P.), Department of Community and Family Medicine (M.E.D.), Department of Sociology (M.E.D., L.K.G.), Duke Law School (G.L.), and Division of Cardiology, Department of Medicine, Duke University Medical Center (E.D.P.), Duke University, Durham, NC. matthew.dupre@dm.duke.edu.

Circulation. Cardiovascular Quality and Outcomes

|April 16, 2015

Summary

Divorce increases the risk of acute myocardial infarction (AMI), particularly for women with multiple divorces. These elevated risks persist even after remarriage, highlighting divorce as a significant cardiovascular health concern.

Keywords:

divorce myocardial infarction sociological factors

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Area of Science:

Cardiovascular Health
Sociology
Public Health

Background:

Divorce is a significant life stressor with known economic, emotional, and physical health impacts.
The cumulative effect of divorce on acute myocardial infarction (AMI) risk remains largely unexplored.
This study addresses the association between lifetime divorce exposure and AMI incidence in US adults.

Purpose of the Study:

To investigate the relationship between experiencing divorce and the risk of developing acute myocardial infarction (AMI).
To examine how the number of divorces and remarriage status influence AMI risk in men and women.
To identify divorce as a potential modifiable risk factor for cardiovascular disease.

Main Methods:

Utilized nationally representative data from a prospective cohort of 15,827 ever-married US adults aged 45-80.
Followed participants biennially from 1992 to 2010, collecting data on divorce history and AMI events.
Employed competing-risk hazard models to analyze the association between divorce and AMI, adjusting for multiple risk factors.

Main Results:

Individuals who were divorced had consistently higher age-specific rates of AMI compared to continuously married individuals.
Women with one or more divorces experienced significantly higher AMI risks, with risks escalating with multiple divorces (HR=1.77 for ≥2 divorces).
Men with a history of two or more divorces showed elevated AMI risks (HR=1.30), while remarried men had no significant increase in risk.

Conclusions:

Divorce is identified as a significant risk factor for acute myocardial infarction (AMI).
The risk of AMI associated with divorce is particularly pronounced in women, especially those with multiple divorce experiences.
Remarriage does not mitigate the elevated AMI risks associated with divorce in women.