Intraglomerular micrometastasis of squamous cell carcinoma

Area of Science:

• Nephrology
• Oncology
• Pathology

Background:

• Intraglomerular metastasis is an uncommon presentation of widespread cancer.
• Penile squamous cell carcinoma can disseminate, though glomerular involvement is rare.

Purpose of the Study:

• To report a case of intraglomerular metastatic carcinoma.
• To highlight the diagnostic significance of incidental glomerular findings in kidney biopsies.

Main Methods:

• A kidney biopsy was performed on a 62-year-old male with acute renal failure.
• Histopathological examination revealed a proliferative lesion within a glomerulus.
• Immunohistochemical staining confirmed the presence of squamous cell carcinoma markers.

Main Results:

• An incidental finding of a metastatic carcinoma lesion within a glomerulus was identified.
• The lesion showed highly atypical epithelial cells within a capillary loop and urinary space.
• Immunoreactivity confirmed the metastatic origin from squamous cell carcinoma.

Conclusions:

• Circulating tumor cells can occasionally deposit in glomeruli.
• Intraglomerular metastasis may present as an incidental finding in kidney biopsies.
• This emphasizes the importance of thorough renal biopsy evaluation in patients with malignancy and renal dysfunction.