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Lanthanum, constipation, bafflying X-rays and a perforated colonic diverticulum.
Asher Korzets1, Inna Tsitman2, Netta Lev1
1Department of Nephrology and Hypertension , Hasharon Hospital, Rabin Medical Center, Sackler School of Medicine , Tel Aviv University , Israel.
Clinical Kidney Journal
|April 16, 2015
Summary
Lanthanum carbonate, used by dialysis patients, can cause constipation and intense gastrointestinal radio-opacity. This case highlights potential complications, including colonic perforation, associated with its use.
Area of Science:
- Nephrology
- Gastroenterology
- Radiology
Background:
- Lanthanum carbonate (LC) is a phosphate binder for dialysis patients.
- Known side effects include abdominal pain and constipation.
- LC tablets appear as radio-opaque deposits on radiological imaging, potentially causing misinterpretation.
Purpose of the Study:
- To discuss a case of peritonitis secondary to perforated colonic diverticulum in an elderly patient on peritoneal dialysis and LC.
- To explore the potential association between LC use, worsening constipation, and complications of diverticular disease.
Main Methods:
- Case report presentation.
- Review of patient's medical history and treatment.
- Discussion of pharmacological properties of Lanthanum carbonate.
- Analysis of radiological findings.
Main Results:
- An elderly patient on peritoneal dialysis and LC presented with peritonitis.
- The peritonitis was secondary to a perforated colonic diverticulum.
- Radiological studies showed intense radio-opaque deposits from LC throughout the GI tract.
Conclusions:
- Lanthanum carbonate use may be associated with severe constipation.
- Constipation and radio-opaque deposits could potentially exacerbate or complicate colonic diverticular disease.
- Further investigation into the gastrointestinal safety profile of LC in patients with pre-existing conditions is warranted.
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