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Updated: Apr 14, 2026

Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
Osteogenesis imperfecta, pseudoachalasia, and gastric cancer
Dilsa Mizrak1, Ali Alkan1, Batuhan Erdogdu2
1Department of Medical Oncology, Ankara University School of Medicine, 06300 Ankara, Turkey.
Abstract:
Osteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia where repeated treatment of pneumatic dilation and stent replacement was unsuccessful; therefore, surgery was performed. Pathology showed gastric adenocarcinoma unexpectedly. Chemotherapy was given after assessing dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can be deficient in OI patients. This is the first report of gastric cancer mimicking achalasia in a patient with OI.
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