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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Histone deacetylases and atherosclerosis.

Xia-xia Zheng1, Tian Zhou1, Xin-An Wang1

  • 1Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.

Atherosclerosis
|April 16, 2015
PubMed
Summary

Histone deacetylases (HDACs) are key players in atherosclerosis, a major cause of cardiovascular disease. This review explores how HDACs and their inhibitors (HDACi) impact atherosclerosis progression.

Keywords:
Endothelial cellsHDACsMacrophage cellsPlaqueThrombosisVascular smooth muscle cells

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Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Medical Research

Background:

  • Atherosclerosis is a prevalent pathological process underlying cardiovascular diseases.
  • It involves the formation of complex atherosclerotic plaques in arteries.
  • Histone deacetylases (HDACs) have emerged as critical regulators in arteriosclerosis.

Purpose of the Study:

  • To review the role of HDACs in the development and progression of atherosclerosis.
  • To summarize the impact of histone deacetylase inhibitors (HDACi) on atherosclerosis.
  • To highlight potential therapeutic strategies targeting HDACs for cardiovascular disease.

Main Methods:

  • Literature review of studies investigating HDACs and atherosclerosis.
  • Analysis of preclinical and clinical data on HDAC inhibition in cardiovascular disease models.
  • Synthesis of current evidence on the molecular mechanisms linking HDACs to plaque formation.

Main Results:

  • HDACs are implicated in various stages of atherosclerotic plaque development.
  • HDAC inhibition demonstrates potential in modulating key cellular processes involved in atherosclerosis.
  • Specific HDAC isoforms may have distinct or opposing roles in cardiovascular disease.

Conclusions:

  • HDACs represent a significant therapeutic target for managing atherosclerosis.
  • HDAC inhibitors offer a promising avenue for novel cardiovascular disease treatments.
  • Further research is needed to elucidate specific HDAC functions and optimize HDACi therapies.