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Histone deacetylases and atherosclerosis

Xia-xia Zheng1, Tian Zhou1, Xin-An Wang1

  • 1Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.

Atherosclerosis
|April 16, 2015
PubMed

Insights

Histone deacetylases (HDACs) are key players in atherosclerosis, a major cause of cardiovascular disease. This review explores how HDACs and their inhibitors (HDACi) impact atherosclerosis progression.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Medical Research

Background:

  • Atherosclerosis is a prevalent pathological process underlying cardiovascular diseases.
  • It involves the formation of complex atherosclerotic plaques in arteries.
  • Histone deacetylases (HDACs) have emerged as critical regulators in arteriosclerosis.

Purpose of the Study:

  • To review the role of HDACs in the development and progression of atherosclerosis.
  • To summarize the impact of histone deacetylase inhibitors (HDACi) on atherosclerosis.
  • To highlight potential therapeutic strategies targeting HDACs for cardiovascular disease.

Main Methods:

  • Literature review of studies investigating HDACs and atherosclerosis.
  • Analysis of preclinical and clinical data on HDAC inhibition in cardiovascular disease models.
  • Synthesis of current evidence on the molecular mechanisms linking HDACs to plaque formation.

Main Results:

  • HDACs are implicated in various stages of atherosclerotic plaque development.
  • HDAC inhibition demonstrates potential in modulating key cellular processes involved in atherosclerosis.
  • Specific HDAC isoforms may have distinct or opposing roles in cardiovascular disease.

Conclusions:

  • HDACs represent a significant therapeutic target for managing atherosclerosis.
  • HDAC inhibitors offer a promising avenue for novel cardiovascular disease treatments.
  • Further research is needed to elucidate specific HDAC functions and optimize HDACi therapies.

Keywords:
Endothelial cellsHDACsMacrophage cellsPlaqueThrombosisVascular smooth muscle cells

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