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Related Experiment Video

Updated: Apr 14, 2026

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

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Published on: May 10, 2024

Negative pressure therapy for closed spine incisions: a pilot study.

Diana A Glaser¹, Christine L Farnsworth², Eric S Varley³

¹Rady Children's Hospital, Orthopedic Biomechanics Research Center, San Diego, CA.

Wounds : a Compendium of Clinical Research and Practice

|April 16, 2015

Summary

Negative pressure therapy (NPT) shows promise for closed spinal incisions, improving scar appearance and potentially enhancing healing strength. This could reduce risks of wound dehiscence and infection in high-risk patients.

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Area of Science:

Biomedical Engineering
Surgical Innovation
Wound Healing Research

Background:

Negative pressure therapy (NPT) is established for open wounds and infections.
Its efficacy on closed spinal incisions remains unevaluated.
Spinal surgery incisions are susceptible to complications like dehiscence and infection.

Purpose of the Study:

To evaluate the impact of NPT on closed spinal incisions.
To assess biomechanical and histological outcomes after NPT application.
To compare NPT with standard dry dressings in a porcine model.

Main Methods:

Midline spine incisions in 8 pigs were treated with either NPT or standard dry dressings.
Incisions were analyzed after 3 and 5 days.
Evaluations included biomechanical testing (failure load, energy, stress), histology, and scar scale assessment.

Main Results:

NPT significantly improved scar scale height grade compared to controls (P=0.026).
Biomechanical properties (failure load, energy, stress) showed a trend toward improvement with NPT.
Histological analysis found no significant difference in incision scar width between groups.

Conclusions:

NPT on closed incisions demonstrates a trend towards improved early healing strength.
NPT significantly enhances incision appearance, reducing scar height.
NPT may improve incision integrity, minimizing dehiscence and infection risk, benefiting high-risk patients.