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Updated: Apr 14, 2026

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
Published on: January 12, 2019
Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva
Oksana V Budinskaya1, Elias D Kontogiorgos2, Meredith Brownlee2
1Department of Diagnostic Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX;
Unlabelled:
This study was designed to determine if vacuum-induced suction increased the number of blood vessels in healthy dog gingiva as a prelude to future studies testing vacuum therapy for improving local blood supply and controlling periodontal disease.
Methods:
The buccal gingiva of five dogs was treated with subatmospheric pressure for 5 days, with untreated tissues acting as controls. Biopsies were analyzed for vascular endothelial growth factors (VEGF) and blood vessels were counted.
Results:
VEGF and vessel numbers were elevated in treatment groups compared to controls (P < 0.05).
Conclusion:
A single daily application of subatmospheric pressure might be beneficial for healing damaged or diseased gingival tissues. .
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