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Changes within the intestinal flora of broilers by colonisation with Campylobacter jejuni
Berliner Und Munchener Tierarztliche Wochenschrift
|April 17, 2015
Summary
Campylobacter jejuni significantly alters chicken intestinal microbiota, potentially causing diarrhea. Understanding this interaction is crucial for developing new strategies against this common foodborne illness.
Area of Science:
- Food Safety
- Microbiology
- Animal Health
Background:
- Campylobacteriosis is a leading bacterial zoonotic foodborne infection in Europe, primarily linked to chicken meat.
- Current strategies to reduce Campylobacter colonization in chickens and human disease have limited effectiveness.
- New insights into Campylobacter's host interactions are essential for improved control measures.
Purpose of the Study:
- To investigate the impact of Campylobacter jejuni and Campylobacter coli colonization on the intestinal microbiota of chickens.
- To analyze changes in bacterial populations and overall microbial community structure during Campylobacter infection.
Main Methods:
- Analysis of fecal and cecal samples from five Austrian chicken flocks for C. jejuni and C. coli.
- Microbiota analysis using PCR-SSCP, cultural methods (lactic acid bacteria, Enterococci, Staphylococci, Enterobacteriaceae, E. coli, total aerobic counts), and high-throughput sequencing.
- Comparison of microbiota composition between Campylobacter-colonized and non-colonized chickens.
Main Results:
- Detection of changes in the intestinal microbiota associated with C. jejuni colonization across all applied methods.
- Significantly lower bacterial counts in fecal samples positive for C. jejuni, suggesting potential diarrhea.
- PCR-SSCP and high-throughput sequencing indicated differences in microbiota composition between colonized and non-colonized chickens, though the latter was not statistically significant.
Conclusions:
- Campylobacter jejuni interacts with and alters the host's intestinal microflora.
- These findings highlight the need to consider host-microbiota interactions when developing strategies to combat Campylobacter.
- Further research into these interactions can lead to more effective interventions against Campylobacter colonization and disease transmission.
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