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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Manufacturing Solid Dosage Forms from Bulk Liquids Using the Fluid-bed Drying Technology.

Jianping Qi, Y I Lu, Wei Wu1

  • 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China. wuwei@shmu.edu.cn.

Current Pharmaceutical Design
|April 17, 2015
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Summary
This summary is machine-generated.

Fluid-bed drying offers an efficient method for converting liquid medications into stable solid dosage forms. This technology enhances drug delivery systems like solid dispersions and nanoscale formulations.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Solid dosage forms offer superior stability, handling, and patient compliance compared to liquid forms.
  • Transforming liquid medications into solid forms is crucial for improved pharmaceutical applications.
  • Conventional drying methods present limitations in efficiency and temperature control.

Purpose of the Study:

  • To review the state-of-the-art in manufacturing solid dosage forms from bulk liquids using fluid-bed drying technology.
  • To highlight the advantages and applications of fluid-bed drying in pharmaceutical formulation.
  • To explore the use of fluid-bed drying in advanced drug delivery systems.

Main Methods:

  • Review of existing literature on fluid-bed drying technology for pharmaceutical applications.
  • Analysis of fluid-bed drying's efficiency in solvent removal and formulation manufacturing.
  • Examination of fluid-bed drying's role in creating solid dispersions, inclusion complexes, and nano-formulations.

Main Results:

  • Fluid-bed drying is a highly efficient, one-step process for solvent removal at low temperatures.
  • This technology enables the manufacturing of solid dosage forms, including pellets.
  • Fluid-bed drying is applicable to various advanced drug delivery systems, enhancing their properties.

Conclusions:

  • Fluid-bed drying presents a significant advancement in transforming liquid origins into solid dosage forms.
  • Its efficiency, mild operating conditions, and versatility make it ideal for modern pharmaceutical manufacturing.
  • The technology shows great promise for developing sophisticated drug delivery systems, including nanoscale formulations.