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Updated: Jun 19, 2026

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
Plant-derived extracellular vesicles for cancer therapy: Biological features, therapeutic mechanisms and
Zibo Wei1, Jinlong Yang2, Yuning Wei3
1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Abstract:
Plant-derived extracellular vesicles (PDEVs) are nanoscale particles isolated from plant tissues that carry proteins, lipids, nucleic acids and secondary metabolites, and function as mediators of intercellular communication. PDEVs have been increasingly investigated in both basic research and translational medicine. Owing to their intrinsic anticancer activity, favorable biocompatibility, and capacity for cargo association/loading and delivery, PDEVs are being explored as nanotherapeutics and drug delivery systems for cancer treatment. This review summarizes the biological features of PDEVs, their mechanisms of action in cancer therapy, and current strategies for engineering multifunctional PDEV-based therapeutic platforms. Finally, the review discusses their potential as drug delivery platforms and analyzes current strategies, advantages, and challenges related to clinical translation. This review aims to advance understanding of PDEV biology and support their future clinical development.
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