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Prevalence and incidence of ischemic heart disease in multiple sclerosis: A population-based validation study

Ruth Ann Marrie1, Bo N Yu1, Stella Leung1

  • 1University of Manitoba, Health Sciences Centre, GF 533, 820 Sherbrook Street, Winnipeg, MB, Canada R3A 1R9.

Multiple Sclerosis and Related Disorders
|April 17, 2015
PubMed
Abstract

Insights

Multiple sclerosis (MS) patients have a higher incidence of ischemic heart disease (IHD) before age 60. This study validated administrative definitions to assess IHD prevalence and incidence in MS populations.

Area of Science:

  • Cardiovascular Epidemiology
  • Neurology
  • Health Services Research

Background:

  • Limited data exist on ischemic heart disease (IHD) risk in multiple sclerosis (MS).
  • Administrative case definitions for IHD in MS require validation for accurate incidence and prevalence estimation.

Purpose of the Study:

  • To validate administrative case definitions for IHD.
  • To estimate the incidence and prevalence of IHD in a multiple sclerosis population using validated definitions.

Main Methods:

  • Utilized administrative data to identify multiple sclerosis (MSPOP) and matched general population (GPOP) cohorts.
  • Developed and validated IHD case definitions using ICD-9/10 codes and prescription claims against medical records.
  • Applied validated definitions to estimate IHD prevalence and incidence in MS and GPOP cohorts.

Main Results:

  • Moderate agreement (kappa=0.66) was found between administrative definitions and medical records for IHD.
  • In 2005, IHD prevalence was 6.77% in MSPOP vs. 6.11% in GPOP.
  • IHD prevalence and incidence were higher in MSPOP compared to GPOP, particularly in individuals under 60 years old.

Conclusions:

  • Over 5% of the multiple sclerosis population studied has ischemic heart disease.
  • The incidence of IHD is elevated in individuals with MS younger than 60 years.
  • Further research is necessary to understand and address the increased IHD risk in the MS population.
Keywords:
Administrative dataCardiac diseaseIncidenceMultiple sclerosisPrevalenceValidation

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