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Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach
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Pcf11 orchestrates transcription termination pathways in yeast

Pawel Grzechnik1, Michal Ryszard Gdula2, Nick J Proudfoot3

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;

Genes & Development
|April 17, 2015
PubMed
Summary

The NRD complex, including Nrd1, Nab3, and Sen1, terminates transcription of short noncoding RNAs (ncRNAs) in yeast. Pcf11 is also crucial for this NRD-dependent termination, facilitating RNA polymerase II pausing and Sen1 activity.

Keywords:
CTD phosphorylationNRD complexcleavage and polyadenylation complexnoncoding RNAtranscription termination

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