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Updated: Apr 14, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
Published on: April 11, 2025
Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
Marion Lapierre1,2,3,4, Audrey Castet-Nicolas5,6,7,8,9, Delphine Gitenay10,11,12,13
1IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France. marion.lapierre@inserm.fr.
Abstract:
RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has been implicated in the control of energy expenditure, behavior, cognition, mammary gland development and intestinal homeostasis. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. During the past years, several papers have reported evidences linking RIP140 to hematologic malignancies. Among them, two recent studies with correlative data suggested that gene expression signatures including RIP140 can predict survival in chronic lymphocytic leukemia (CLL). This review aims to summarize the literature dealing with the expression of RIP140 in CLL and to explore the potential impact of this factor on transcription pathways which play key roles in this pathology.
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