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Updated: Apr 14, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum(0)-Catalyzed Indolyne Insertion into Bis(pinacolato)diboron Followed by Site-Selective Suzuki-Miyaura
Manish Pareek1, Thomas Fallon1, Martin Oestreich1
1Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany.
Abstract:
Indolynes are converted into previously unprecedented indole building blocks by platinum(0)-catalyzed insertion into a symmetrically substituted boron-boron bond. The two boron sites in these indoles must be differentiated in a subsequent step, and the 6,7-bis[(pinacolato)boryl]indole was shown to undergo site-selective Suzuki-Miyaura cross-coupling with perfect C7 selectivity. The net reaction is the regioselective installation of two different substituents in the C6 and C7 positions of a 6,7-indolyne precursor.
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