Related Experiment Video
Updated: Apr 14, 2026
Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction
Rui-Rong Ye1, Cai-Ping Tan, Yan-Nan Lin
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
Abstract:
In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.
More Related Videos
06:00Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
Published on: May 14, 2016
06:57Author Spotlight: Fluorescence-Based Quantification of Mitochondrial Membrane Potential and Superoxide Levels Using Live Imaging in HeLa Cells
Published on: May 12, 2023