Jove
Visualize
Contact Us

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

34.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.5K
Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

26.4K
26.4K
Replication in Eukaryotes01:29

Replication in Eukaryotes

19.4K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
19.4K
Replication in Eukaryotes02:31

Replication in Eukaryotes

208.5K
Overview
208.5K
Telomeres and Telomerase02:41

Telomeres and Telomerase

8.3K
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Nutriepigenome.

Genes·2023
Same author

Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms.

Cells·2022
Same author

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.

Aging cell·2022
Same author

Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial.

Journal of clinical psychology·2020
Same author

Mitochondrion at the Crossroad Between Nutrients and Epigenome.

Frontiers in endocrinology·2019
Same author

Longevity: Lesson from Model Organisms.

Genes·2019
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 14, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.4K

Longevity: epigenetic and biomolecular aspects.

Giusi Taormina, Mario G Mirisola

    Biomolecular Concepts
    |April 18, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Dietary interventions like calorie restriction modulate aging pathways, including insulin/IGF-1 signaling. Emerging evidence suggests epigenetics plays a crucial role in how diet impacts longevity.

    More Related Videos

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
    10:39

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

    Published on: September 17, 2020

    6.9K
    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
    09:10

    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

    Published on: January 30, 2026

    918

    Related Experiment Videos

    Last Updated: Apr 14, 2026

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
    10:08

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

    Published on: May 18, 2022

    4.4K
    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
    10:39

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

    Published on: September 17, 2020

    6.9K
    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
    09:10

    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

    Published on: January 30, 2026

    918

    Area of Science:

    • Gerontology and Molecular Biology
    • Investigates the molecular underpinnings of aging and longevity.

    Background:

    • Aging is a complex process with numerous proposed theories and molecular mechanisms.
    • Simple model organisms have been instrumental in identifying genes and pathways linked to longevity regulation.
    • The insulin/IGF-1 signaling pathway is a conserved and critical regulator of lifespan.

    Purpose of the Study:

    • To review well-characterized aging pathways.
    • To highlight the role of epigenetic mechanisms in diet-mediated longevity.

    Main Methods:

    • Literature review of aging theories and molecular mechanisms.
    • Analysis of studies on dietary interventions and their effects on aging pathways.
    • Focus on the interplay between diet, epigenetics, and longevity.

    Main Results:

    • Dietary interventions such as calorie restriction (CR), intermittent fasting, and protein/amino acid restriction extend mammalian lifespan.
    • These dietary interventions modulate the insulin/IGF-1 pathway.
    • Recent findings indicate that epigenetic mechanisms are involved in the long-term effects of diet on aging.

    Conclusions:

    • The insulin/IGF-1 pathway is a key target for lifespan extension through dietary means.
    • Epigenetic modifications represent a significant mechanism through which diet influences longevity.
    • Understanding these pathways is crucial for developing strategies to promote healthy aging.