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Updated: Feb 11, 2026

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Published on: February 25, 2022
Pituitary disorders in pregnancy
Alexandra Chrisoulidou1, Maria Boudina1, Niki Karavitaki2
1Unit of Endocrinology, Theagenio Hospital, Aristotle University of Thessaloniki, Greece.
Abstract:
The pituitary gland is significantly affected during gestation in terms of both size and function. Due to this physiologic adaptation, endocrine evaluation and interpretation of imaging is far more complex than in the non-pregnant state. Pituitary disorders are rare in pregnancy, as they are usually associated with gonadal dysfunction, thereby posing difficulties with fertility. This review will focus on pituitary adenomas (prolactinomas, GH-secreting and ACTH-secreting), their diagnostic handicaps and the recommendations for treatment. We will also discuss the two pituitary disorders encountered in pregnancy, Sheehan's syndrome and lymphocytic hypophysitis.
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