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Cystic fibrosis in a retro-positive child
Praveen Sharma, N Arthi, Sagar Bhattad
1Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian Journal of Pathology & Microbiology
|April 18, 2015
Insights
This case report details a rare instance of cystic fibrosis and retroviral positivity in a malnourished child. The child presented with severe lung, pancreas, and colon issues, complicated by viral pneumonia and meningitis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Genetics
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
- Retroviral infections can present with diverse clinical manifestations.
- Malnutrition is a common comorbidity in children with chronic diseases.
Observation:
- A severely malnourished pediatric patient presented with symptoms suggestive of advanced cystic fibrosis.
- The patient exhibited pulmonary, pancreatic, and colonic involvement characteristic of CF.
- Superimposed infections included herpes simplex virus interstitial pneumonia and lymphocytic meningitis.
Findings:
- The case highlights a rare co-occurrence of cystic fibrosis and retroviral positivity.
- The clinical presentation was complicated by severe malnutrition and opportunistic infections.
- This association underscores the complexity of managing dual pathologies in pediatric patients.
Implications:
- This case emphasizes the need for comprehensive diagnostic approaches in complex pediatric cases.
- Understanding rare disease associations can improve clinical management and patient outcomes.
- Further research may elucidate shared or interactingPathways between CF and retroviral infections.
Abstract:
We present a rare association of cystic fibrosis and retro positivity in a grossly malnutrited child. The child had pulmonary, pancreatic and colonic manifestations with superadded herpes simplex virus interstitial pneumonia and lymphocytic meningitis.