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Percutaneous Needle Puncture Technique to Create a Rabbit Model with Traumatic Degenerative Disk Disease
Dong Won Kim1, Hyoung-Joon Chun2, Sang-Kook Lee3
1Department of Anesthesiology, Hanyang University Medical Center, College of Medicine, Hanyang University, Seoul, Korea.
World Neurosurgery
|April 19, 2015
Summary
A new percutaneous technique effectively creates a rabbit model for degenerative disk disease. This reliable model aids in testing new treatments for this common condition.
Area of Science:
- Biomedical research
- Animal modeling
- Spinal research
Background:
- Degenerative disk disease (DDD) pathogenesis and management require further investigation.
- Reliable animal models are crucial for advancing DDD research.
- A novel percutaneous technique is presented to establish a rabbit model of DDD.
Purpose of the Study:
- To develop and validate a percutaneous technique for creating a rabbit model of degenerative disk disease.
- To assess the reproducibility and efficacy of this novel modeling technique.
Main Methods:
- Ten New Zealand white rabbits underwent percutaneous injury at lumbar intervertebral disk levels (L2-L3, L3-L4, L4-L5) under C-arm guidance.
- Magnetic resonance imaging (MRI) and X-rays were used for serial assessment (1-20 weeks), with histology at 24 weeks.
Main Results:
- Significant disk height narrowing observed by 9 weeks post-injury.
- MRI confirmed disk degeneration starting at 9 weeks and complete by 15 weeks.
- Histological examination validated degeneration in all injured disks; no osteophytes formed.
Conclusions:
- The described percutaneous technique yields a reproducible and effective rabbit model for degenerative disk disease.
- This model is suitable for evaluating the safety and efficacy of potential DDD treatments, including stem cell therapy.
