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Association between lipids profile and thyroid parameters in euthyroid diabetic subjects: a cross-sectional study
Yun Zhang1, Ping Lu2, Ling Zhang3
1Department of Endocrinology, Henan Province People's Hospital & Zhengzhou University People' Hospital, Zhengzhou City, Henan Province, P R China. wing.1120@163.com.
BMC Endocrine Disorders
|April 19, 2015
Summary
Higher thyroid-stimulating hormone (TSH) is linked to increased total cholesterol and LDL-c in euthyroid diabetic women. This suggests a connection between thyroid function and lipid profiles in this population.
Area of Science:
- Endocrinology
- Cardiovascular Disease
- Metabolic Disorders
Background:
- Emerging evidence suggests subclinical thyroid dysfunction may impact atherosclerosis.
- Euthyroid individuals with higher TSH and lower thyroid hormones may face increased cardiovascular risk.
Purpose of the Study:
- To investigate the association between thyroid parameters and lipid profiles.
- Focus on a cohort of euthyroid individuals with type 2 diabetes.
Main Methods:
- Recruited 462 euthyroid type 2 diabetes subjects (302 males, 160 females).
- Collected clinical, anthropometric data, and measured serum TSH, FT4, FT3, TPO-Ab, lipids, and glucose.
- Utilized correlation and regression analyses to assess associations.
Main Results:
- Thyroid-stimulating hormone (TSH) was higher in females.
- TSH positively correlated with total cholesterol (TC) and LDL-c in euthyroid diabetic women.
- No significant association found between TPO-Ab and lipid levels.
Conclusions:
- TSH is positively associated with serum TC and LDL-c in euthyroid diabetic women.
- Further research is needed to elucidate the mechanisms linking thyroid function and lipid metabolism in type 2 diabetes.