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[Complications following cell therapy].

J Bohl1, H H Goebel, L Pötsch

  • 1Abteilung für Neuropathologie, Johannes-Gutenberg-Universität Mainz, Bundesrepublik Deutschland.

Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine
|January 1, 1989
PubMed
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Fresh-cell injections, used to boost vitality, can cause severe neurological complications, including fatal respiratory and cardiovascular failure. These adverse events are likely immune-mediated allergic reactions to animal nervous tissue, similar to animal models of allergic encephalomyelitis.

Area of Science:

  • Immunology
  • Neurology
  • Toxicology

Background:

  • Fresh-cell injections from animals are permitted in Germany as a roborant therapy.
  • The Federal Health Organization provisionally banned "sicca-cell" preparations in 1987 due to serious safety concerns.
  • Previous publications since 1955 have documented life-threatening and fatal complications associated with fresh-cell therapy.

Observation:

  • Two new cases of severe adverse events following fresh-cell injections are presented.
  • Case 1: A 69-year-old woman developed ascending paralysis and respiratory failure, leading to death, consistent with Landry-Guillain-Barré-Strohl syndrome.
  • Case 2: A 76-year-old woman died from cardiovascular failure, with autopsy revealing clostridial infection and Landry-Guillain-Barré syndrome affecting the autonomic nervous system.

Findings:

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  • The complications are hypothesized to be immune-mediated allergic reactions to heterologous antigenic material, particularly nervous tissues, from the injected preparations.
  • This immune response may lead to inflammatory processes in the peripheral and central nervous systems, including perivenous leukoencephalopathy.
  • The observed human conditions closely resemble established animal models: experimental allergic encephalomyelitis (EAEM) and experimental allergic neuritis (EAN).

Implications:

  • The study highlights the significant risks associated with fresh-cell injections, including acute autonomic failure.
  • It emphasizes the need for specialized autopsy techniques to thoroughly examine the entire nervous system in suspected cases.
  • The findings question the continued use of fresh-cell therapy and advocate for a re-evaluation of its safety and efficacy.