Related Experiment Video
Updated: Apr 14, 2026

Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
Differential sequential patterns supporting insulin therapy of new-onset type 1 diabetes
Rafał Deja1, Wojciech Froelich2, Grażyna Deja3
1Department of Computer Science, Academy of Business in Dabrowa Gornicza, Cieplaka 1c, Dabrowa Gornicza, Poland. rdeja@wsb.edu.pl.
Background:
In spite of numerous research efforts on supporting the therapy of diabetes mellitus, the subject still involves challenges and creates active interest among researchers. In this paper, a decision support tool is presented for setting insulin therapy in new-onset type 1 diabetes.
Methods:
The concept of differential sequential patterns (DSPs) is introduced with the aim of representing deviations in the patient's blood glucose level (BGL) and the amount of insulin injections administered. The decision support tool is created using data mining algorithms for discovering sequential patterns.
Results:
By using the DSPs, it is possible to support the physician's decisionmaking concerning changing the treatment (i.e., whether to increase or decrease the insulin dosage). The other contributions of the paper are an algorithm for generating DSPs and a new method for evaluating nocturnal glycaemia. The proposed qualitative evaluation of nocturnal glycaemia improves the generalization capabilities of the DSPs.
Conclusions:
The usefulness of the proposed approach was evident in the results of experiments in which juvenile diabetic patients actual data were used. It was confirmed that the proposed DSPs can be used to guide the therapy of numerous juvenile patients with type 1 diabetes.
More Related Videos
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes: Symptoms, Diagnosis, and Complications

