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Published on: June 25, 2014
Modelling endogenous insulin concentration in type 2 diabetes during closed-loop insulin delivery
Yue Ruan1,2, Hood Thabit3, Malgorzata E Wilinska4,5
1Department of Paediatrics, University of Cambridge, Cambridge, UK. yr233@cam.ac.uk.
A new model for endogenous insulin concentration in type 2 diabetes (T2D) was developed. This model accounts for glucose-dependent and independent insulin secretion, crucial for simulating closed-loop insulin delivery systems in T2D patients.
Area of Science:
- Biomedical Engineering
- Computational Physiology
- Diabetes Research
Background:
- Closed-loop insulin delivery systems are advancing for type 1 diabetes (T1D).
- Adapting these systems for type 2 diabetes (T2D) requires new simulation tools.
- Existing T1D simulators lack a model for posthepatic endogenous insulin concentration, vital for T2D.
Purpose of the Study:
- To develop and validate a model of posthepatic endogenous insulin concentration in individuals with T2D.
- To create a simulation component essential for evaluating closed-loop insulin delivery in T2D.
Main Methods:
- Evaluated six models for endogenous insulin concentration using plasma glucose and time data.
- Fitted models to data from insulin-naive T2D subjects during two 24-h visits (closed-loop vs. oral agents).
- Employed Bayesian parameter estimation (WinBUGS) and model selection criteria.
Main Results:
- The selected model accurately described 24-h endogenous insulin concentration in T2D.
- Model parameters were plausible and consistent with clinical findings of increased insulin during control periods.
- Excess insulin was attributed to glucose-independent secretion; glucose-dependent secretion was similar between conditions.
Conclusions:
- A validated model for endogenous insulin concentration in T2D, incorporating glucose-dependent and -independent components, was identified.
- This model is suitable for integration into simulation environments for T2D closed-loop insulin delivery research.
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