Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis
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Published on: June 16, 2018
Yi Yang1, Zihao Wang2, Yiming Zhou3
1Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Floor 16, Building 2, 12 Wulumuqizhong Road, Shanghai, 200040, China. fengwu822@qq.com.
Background:
Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.
Methods:
Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed.
Results:
The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).
Conclusions:
The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.
Insights
Interleukin-32 (IL-32) expression is significantly higher in colorectal cancer (CRC) metastases than in primary tumors. This suggests IL-32 may drive CRC metastasis, including lymph node involvement.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Interleukin-32 (IL-32) is an intracellular mediator of inflammation.
- IL-32 signaling involves NF-κB and STAT3 pathways.
Purpose of the Study:
- To investigate the clinical significance of IL-32 expression in colorectal cancer (CRC) metastasis.
- To determine if IL-32 correlates with CRC organic and lymph node metastasis.
Main Methods:
- Immunohistochemistry was used to detect IL-32 expression in 70 CRC patient samples.
- Samples included primary CRC lesions and metastatic lesions.
- Statistical analysis correlated IL-32 expression with metastasis status.
Main Results:
- IL-32 positive rates were significantly higher in CRC organic metastasis compared to primary CRC (P < 0.05).
- IL-32 positive rates were significantly higher in primary CRC with lymph node metastasis than without (P < 0.05).
Conclusions:
- IL-32 expression levels may influence the N stage (lymph node metastasis) of CRC.
- IL-32 may play a role in promoting organic and lymph node metastasis in colorectal cancer.
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