Related Experiment Video
Updated: Apr 14, 2026
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
André Fernandes d'Alessandro1, Fábio Roberto Pinto2, Chin Shien Lin2
1Discipline of Head and Neck Surgery, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Introduction:
Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis.
Objective:
The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival.
Methods:
Forty surgically treated patients were retrospectively included.
Results:
Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR=39.3; p=0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis.
Conclusion:
Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor.
