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Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

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Published on: January 19, 2020

3D-nanostructured boron-doped diamond for microelectrode array neural interfacing.

Gaëlle Piret¹, Clément Hébert², Jean-Paul Mazellier³

¹INSERM, UA01, Clinatec Laboratory, Biomedical Research Center Edmond J. Safra, F-38 000 Grenoble, France; Université Grenoble Alpes, UA01, Clinatec Laboratory, Biomedical Research Center Edmond J. Safra, F-38 000 Grenoble, France; CEA, LETI, Clinatec, F-38000 Grenoble, France.

|April 20, 2015

Summary

This summary is machine-generated.

Boron-doped diamond (BDD) microelectrodes show promise for neural implants. These 3D-nanostructured BDD electrodes support neural cell growth and enable high-fidelity recording of neural activity.

Keywords:

Biocompatibility Electrical stimulation Electrode Electrophysiology Neural prosthesis Neural recording

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Last Updated: Apr 14, 2026

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Published on: February 12, 2020

Area of Science:

Biomaterials Science
Neuroscience
Materials Engineering

Background:

Developing ideal electrode materials for neural implants is crucial for longevity, biocompatibility, and signal quality.
Current materials often fall short in providing a balance of recording fidelity, stimulation capability, and long-term stability.

Purpose of the Study:

To evaluate 3D-nanostructured boron-doped diamond (BDD) as a novel material for neural interfacing.
To assess the biocompatibility, recording performance, and stimulation potential of BDD microelectrodes.

Main Methods:

Fabrication of 3D-nanostructured BDD microelectrode arrays using a carbon nanotube template.
In vitro assessment of neural cell attachment, survival, and neurite extension on BDD.
In vitro and ex vivo electrophysiological recordings of neural activity (local-field potentials, single units).
Electrochemical characterization using cyclic voltammetry to determine potential window and charge storage capacity.

Main Results:

3D-nanostructured BDD supported neural cell attachment, survival, and neurite extension.
BDD microelectrodes demonstrated low impedance and low intrinsic recording noise.
Detection of low-amplitude neural signals (10-20 μV) and neural bursts was achieved.
Electrochemical tests revealed a wide potential window (~3 V) and high charge storage capacity (10 mC·cm⁻²).

Conclusions:

3D-nanostructured BDD is a promising material for neural interfacing applications.
Its properties suggest suitability for biocompatible neural implants for nervous system exploration and rehabilitation.
BDD offers a potential solution for advanced neural prosthetics requiring high performance and longevity.