Related Experiment Video
Updated: Apr 14, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
Published on: March 28, 2025
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
Xi Chen1,2, Yun Lu1,2, Zhengguo Zhang1,2
1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Abstract:
Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in understanding the regulatory role of Sirt1 in immune responses as well as how Sirt1 translates metabolic cues to immune signals, which would bring new insights into both pathogenesis and potential therapeutic strategies of a variety of immune-related diseases, such as cancer, microbial infection, autoimmune diseases and transplantation.
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